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COC1C=C2C(=NC=NC2=CC=1OCCCN1CCCCC1)N1CCN(CC1)C(=O)NC1C=CC(=CC=1)OC(C)C
IDX184 is a second generation
Zhong Yao Cai
Chemical Name: 3-[5-(aminomethyl)-1-oxo-2
CGP 35348 Histone Methyltransferase COC1C=C2C(=NC=NC2=CC=1OCCCN1CCCCC1)N1CCN(CC1)C(=O)NC1C=CC(=CC=1)OC(C)CCGP 35348 is a selective antagonist of aminobutyric acidB (GABAB) receptor with IC50 value of 34 M . The GABAB receptor is a metabotropic transmembrane receptors for GABA that is linked via G protein to potassium channel. It stimulates the opening of K+ channel and hyperpolarize the neuron. CGP 35348 is a selective GABAB receptor antagonist that can penetrate the blood brain barrier. In rat cortex slices, CGP 35348 inhibited the potentiating effect of